教师基本信息：
姓名：郑琰
职称：研究员
电子邮箱：yan_zheng@fudan.edu.cn
办公地点：C601
研究方向：
从事肥胖和营养的分子流行病学研究，应用高通量多组学（尤其是代谢组和人体微生物组）技术发现疾病和饮食的生物标志物，探索饮食与基因交互作用等。
个人简介：
2005年获首都医科大学临床医学学士学位，2008年获复旦大学上海医学院内科学硕士学位。2008-2010年就读于美国Emory大学并获公共卫生硕士学位，2010-2013年就读于美国德州大学公共卫生学院并获流行病学博士学位。2014-2017在美国哈佛大学陈曾熙公共卫生学院从事博士后研究。2017年加入betway必威西汉姆联官方网站，任青年研究员、博士生导师、遗传工程国家重点实验室PI、复旦大学附属中山医院双聘教授，2021年12月聘为复旦大学研究员。
担任中国营养学会营养流行病分会/基础营养学分会委员、Molecular Genetics and Genomics杂志副主编等多个学术兼职职务。以重要作者身份在JAMA、BMJ、Nat Aging、Nat Microbiol、Natl Sci Rev等杂志上发表文章，多篇入选ESI高被引论文，并受到国内外媒体报道。
授课情况：
1. 本科生全英文课程Bioethics；
2. 研究生必修课《科研伦理与规范》
招生专业：
遗传学、生物信息学、生物学、生物医药
科研项目：
1. 国家科学技术部国家重点研发项目（2021-2026 年）课题主持
2. 复旦大学义乌基地项目（2021-2023年）主持
3. 国家科学技术部国家重点研发项目（2019-2023 年）参与
4. 上海市东方学者计划（人才项目）（2019-2012年）
5. 国家自然科学基金面上基金项目（2019-2023年）主持
6. 国家自然科学基金应急基金项目（2018年）主持
7. 上海市浦江人才计划（人才项目）（2018-2019年）
获奖情况：
1. 入选“全球前2%顶尖科学家榜单”（2023，2024年）
2. 中国高被引学者（2022，2023，2024年）
3. 复星奖教金一等奖（2022年）
代表性论文和论著：
1. Shuchun Lin#, Zhonghan Sun#, Xinna Zhu#, Mengjing Wang, Qian Zhang, Jing Qian, Hui Zhang, Zhendong Mei, Yanni Pu, Mengmeng Kong, Peifeng Guo, Xiaofeng Zhou, Jin Li, Xuehui Sun, Liang Ma, Xueli Zhang, Fangqing Zhao, Jing Nie, Shangyu Hong, Jing Chen*, Xiaofeng Wang*, Xiao Li*, Yan Zheng*. Gut microbial ammonia metabolism contributes to the pathogenesis of chronic kidney disease. Nature Microbiology.2025 (Accepted)
2. Chenhao Lin#, Mingfeng Xia#, Yuxiang Dai#, Qingxia Huang#, Zhonghan Sun, Guoqing Zhang, Ruijin Luo, Qianqian Peng, Jinxi Li, Xiaofeng Wang, Huandong Lin, Xin Gao, Huiru Tang, Xia Shen, Sijia Wang, Li Jin*, Xingjie Hao*, Yan Zheng*. Cross-ancestry analysis of Chinese and European populations reveals novel insights into the genetic architecture and disease implications of metabolites. Cell Genomics.2025 Apr 9;5(4):100810.
3. Zhonghan Sun, Yan Zheng. Metabolic diseases in the East Asian populations. Nature Reviews Gastroenterology & Hepatology. 2025. (Online Published)
4. Xiao Li#, Jie Yang#, Xiaofeng Zhou#, Chen Dai, Mengmeng Kong, Linshan Xie, Chenglin Liu, Yilian Liu, Dandan Li, Xiaonan Ma, Yuxiang Dai, Yan Sun, Zhijie Jian, Xiaohuan Guo, Xu Lin, Yixue Li, Liang Sun, Xin Liu, Li Jin, Huiru Tang, Yan Zheng*, and Shangyu Hong*. Ketogenic diet-induced bile acids protect against obesity through increased calorie excretion. Nature Metabolism. 2024 Jul;6(7):1397-1414.
5. Pu Y#, Sun Z#, Zhang H#, Huang Q#, Wang Z, Mei Z, Wang P, Kong M, Yang W, Lin C, Zhou X, Lin S, Huang Q, Huang L, Sun L, Yuan C, Tang H*, Wang X*，Zheng Y*. Gut microbial features and circulating metabolomic signatures of frailty in older adults. Nature Aging. 2024 Sep;4(9):1249-1262.
6. Senying Lai, Yan Yan, Yanni Pu,Shuchun Lin, Jian-Ge Qiu,Bing-Hua Jiang, Marisa Isabell Keller, Mingyu Wang, Peer Bork*, Wei-Hua Chen*, Yan Zheng*. Xing-Ming Zhao*, Enterotypes of the human gut mycobiome. Microbiome. 2023 Aug 11;11(1):179
7. Yuxiang Dai, Zhonghan Sun, Yan Zheng*, Junbo Ge*. Recent advances in the gut microbiome and microbial metabolites alterations of coronary artery disease. Science Bulletin.2023 Mar 30;68(6):549-552.
8. Zhonghan Sun#, Xiong-Fei Pan#, Xiao Li, Limiao Jiang, Ping Hu, Yi Wang, Yi Ye, Ping Wu, Bin Zhao, Jianguo Xu, Mengmeng Kong, Yanni Pu, Manying Zhao, Jianying Hu, Jinfeng Wang, Guo-Chong Chen, Changzheng Yuan, Yongfu Yu, Xiang Gao, Fangqing Zhao, An Pan*, Yan Zheng*. The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case-control Study of Gestational Diabetes Mellitus. Advanced Science. 2023 Jan 22; e2205289.
9. Kang Yao, Yuxiang Dai, Juan Shen, Yi Wang, Huanjie Yang, Runda Wu, Qijun Liao, Hongyi Wu, Xiaodong Fang, Shalaimaiti Shali, Lili Xu, Meng Hao, Chenhao Lin, Zhonghan Sun, Yilian Liu, Mengxin Li, Zhen Wang, Qiang Gao, Shuning Zhang, Chenguang Li, Wei Gao, Lei Ge, Yunzeng Zou, Aijun Sun, Juying Qian, Li Jin, Shangyu Hong*, Yan Zheng*, Junbo Ge*. Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese. National Science Review. 2022 May 31;9(8): nwac102.
10. Yan Zheng, Yanping Li, Ambika Satija, An Pan, Mercedes Sotos-Prieto, Eric Rimm, Walter C. Willett, and Frank B. Hu. Association of Changes in Red Meat Consumption with Total and Cause-Specific Mortality among U.S. Women and Men: Two Large Prospective Cohort Studies. The BMJ. 2019 June 12; doi:10.1136/bmj. I2110.
11. Yan Zheng, Sylvia H Ley, Frank B Hu. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018 Feb;14(2):88-98. Selected in 100 most influential international academic papers in China, 2018.
12. Yan Zheng, JoAnn E. Manson, Changzheng Yuan, Matthew H. Liang, Francine Grodstein, Meir J. Stampfer, Walter C. Willett, and Frank B. Hu. Associations of weight gain from early to middle adulthood with major health outcomes in later life. Journal of the American Medical Association (JAMA). 2017;318(3):255-269.